Endocrine Abstracts

Introduction: Graves’ disease is an autoimmune disease accounting for the majority of hyperthyroidism cases.Aim: We aimed to assess the interrelationships between cardiovascular risk factors, autoimmunity, insulin resistance and treatment in Graves’ disease.Material and methods: We measured free T3 (FT3), free T4 (FT4), TSH, thyrotropin receptor antibodies (TRAb), anti-thyroglobulin and anti-TPO antibodies, thyro...

Introduction: Thyroid dysfunction has been associated with cardiovascular events since it worsens atherogenesis, insulin resistance and dyslipidemia. Thyroid hormones and adipokines interact with each other to regulate metabolism. The impact of thyroid dysfunction on adipokines serum levels remains controversial.Objective: To evaluate the interrelations between thyroid function and cardiovascular risk factors as insulin resistance, lipid profile, inflamm...

Introduction: The interrelationship between autoimmune thyroiditis, Graves’ disease and plasma adipokines levels remains elusive.Aims: We aimed to compare the levels of adiponectin, resistin and PAI-1 levels in patients with autoimmune thyroiditis and Graves’ disease.Subjects and methods: We recorded thyroid function tests, BMI, the levels of total cholesterol (TC), HDL, LDL-cholesterol, triglycerides (TG), apolipoprotein...

Background and objective: Papillary thyroid microcarcinoma (PTMC) is recognized as a separate entity by the World Health Organization. Biological behaviour and clinical outcomes of PTMC are heterogenous. Presence of lymph node metastases (LNM) in this group of patients increases the risk of recurrence and makes optimal management in PTMC controversial (observation, lobectomy with or without preventive central ipsilateral dissection). The aim of this study was to describe risk ...

Background: Overt thyroid dysfunction is associated with an increased cardiovascular risk. The impact of subclinical hypothyroidism and autoimmunity in the increased cardiovascular risk remains controversial. Aim: To evaluate the interrelations between thyroid function, thyroid autoimmunity and cardiovascular risk factors, in patients with autoimmune thyroiditis (AIT).Methods: 353 subjects with AIT were evaluated. We defined three groups based on TSH lev...

Metabolic syndrome (MetS) and type-2 diabetes (T2D) development is critically affected by the loss of phenotypic flexibility (i.e. the difficulty to cope with stressors to maintain metabolic homeostasis). Thus, it is essential to identify key modifiers of phenotypic plasticity that define individual susceptibility to develop T2D. Particularly, there is emerging evidence that alternative mRNA splicing is dysregulated under adverse metabolic-conditions, such as T2D, in several t...

Background: Thyroid hormones modulate the lipoprotein and glucose metabolisms. In hyperthyroidism, insulin resistance is a frequent finding.Aim: To assess interrelationships between thyroid function, autoimmunity, lipid profile, glucose metabolism and other cardiovascular risk factors in patients with Graves’ disease.Methods: We recorded free T3 (FT3), free T4 (FT4), TSH, TSH receptor antibodies (TRAB), parameters of the lipid...

Introduction: Most serum cortisol (SeC) is linked to cortisol binding globulin and albumin. When the synthesis of proteins is reduced or increased, SeC does not reflect the actual free cortisol (FC) (active fraction). Methods for FC analysis are very laborious and expensive, which makes difficult to use them as a routine laboratory tests. Salivary cortisol (SaC) mirrors the FC in serum, being its measurement easier and cheaper. The determination of SaC, instead of tot...

Introduction: In patients with autoimmune thyroiditis, thyroid function appears to be related to increased cardiovascular risk. It was our objective to evaluate the relationship between TSH, insulin resistance, lipid profile, C-reactive protein (CRP) and homocysteine in patients with autoimmune thyroiditis (AIT).Methods: We analyzed the lipid profile, the CRP, anti-thyroid antibodies, homocysteine, folic acid, vitamin B12 levels and the insulin resistanc...

Introduction: Hypoglucemia is one of the most common endocrine symptoms and supposes a challenging in endocrine clinical practise. In most cases, are produced in relation with diabetes (drugs and diet). In other cases, there was an endogenous insulin production which cause the symptoms.Clinical report: A 58-year-old was attended in the Emergency Department with episodes of lightheadedness, diaphoresis, palpitation, tremulousness for month duration. In th...